منابع مشابه
Mapping the networks for pluripotency.
There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play essential roles, and signalling pathways also act to sustain the undifferentiated state. Recent studies have unravelled multiple forms of interconne...
متن کاملRearranging the chromatin for pluripotency
Pluripotent cells are characterized by infinite self-renewal and unrestricted differentiation potential with far-reaching implications in developmental biology and regenerative medicine. Somatic cells can be reprogrammed to a pluripotent state by ectopic expression of defined transcription factors (TFs) such as Oct4, Klf4, Sox2, and c-Myc, generating induced pluripotent stem cells (iPSCs). This...
متن کاملInduced Pluripotency for Translational Research
The advent of induced pluripotent stem cells (iPSCs) has revolutionized the concept of cellular reprogramming and potentially will solve the immunological compatibility issues that have so far hindered the application of human pluripotent stem cells in regenerative medicine. Recent findings showed that pluripotency is defined by a state of balanced lineage potency, which can be artificially ins...
متن کاملCapturing Pluripotency
In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-r...
متن کاملHuman pluripotency
Pluripotent cells have unique properties of self-renewal while maintaining developmental potential to differentiate into all three germ layers. By definition, pluripo-tent cells have no predetermined lineage program, thereby forming the fundamental basis of enquiry and experimental investigations to understand cell fate decisions. Molecular and cellular insights into human pluripotent stem cell...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2011
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3216